There is currently no coherent effort in the grasses for a rational and organized
naming of transcription factors (TFs). The use of GenBank accession numbers, EST names or
locus identifiers provides an impractical mechanism, which often leads to ambiguities, for
example because of multiple entries in GenBank or of several ESTs for the same protein. Thus,
we have adopted a uniform nomenclature for TFs from the grasses, following the lead from
Arabidopsis. This proposal was done in consultation with the Maize Genetics Nomenclature
Committee, the TIGR rice annotation group and by the SUCEST-FUN sugarcane annotation
group.
Nomenclature criteria adopted here: Each transcription factor will have an organism identifier
(Zm for maize, Sb for sorghum, Os for rice and cane for sugarcane), followed by letters that
represent the TF family (e.g., MYB, bHLH, HD, bZIP) and by a number that will start with "1".
Since we realize that many TFs are known by their genetic names, this nomenclature will permit
the use of synonyms. For example, KNOTTED could be named ZmHD1 (KN) and C1 would be
ZmMYB1 (C1). In addition, whenever possible, we will try to have the numbers provide a
historic perspective of which TFs have been first identified. In that regard, since KN and C1
correspond to the founding members of their respective families in maize, they are assigned the
number "1". Whenever possible, an effort will also be made to capture phylogenetic
relationships when numbering the TFs.
We also realize that there are several TFs that have been already named with numbers, as for
example "myb23" or "bZIP5". Whenever possible, we intend to keep the original numbers to
ensure that we minimize confusion. However, we foresee that in some instances, the TFs may
need to be re-named. In those cases, we will communicate the original author of the change and
we will include a note in GenBank indicating to that effect. It should be noted that it is not our
intention to alter the name of existing genes – the database deals primarily with proteins and
when appropriate, the names of the genes (if already available) will be provided for cross-
reference.
Maize Genetics Nomenclature Committee